Acetic acid, 2-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester - Names and Identifiers
Acetic acid, 2-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester - Physico-chemical Properties
Molecular Formula | C10H21NO4
|
Molar Mass | 219.28 |
Density | 1.026±0.06 g/cm3(Predicted) |
Boling Point | 297.4±20.0 °C(Predicted) |
pKa | 8.72±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Acetic acid, 2-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester - Introduction
H2N-PEG2-CH2COOtBu (H2N-PEG2-CH2COOtBu) is an organic compound, which is a compound modified by a polyethylene glycol group (PEG). The following is a description of some properties, uses, preparation and safety information about the compound:
Nature:
-chemical formula: C12H25NO5
-Molecular weight: 267.33g/mol
-Appearance: colorless liquid
-Solubility: can be dissolved in some organic solvents such as chloroform, dimethylformamide
-Melting Point: Below Room Temperature
Use:
H2N-PEG2-CH2COOtBu is mainly used in the biomedical field as a modifier for biologically active substances. Due to the characteristics of its PEG group, the compound can increase the water solubility and Biostability of the drug or compound, and improve its in vivo distribution. In addition, it can also be used as a coating agent for nanoparticles, an immobilized carrier for enzymes, etc.
Method:
The preparation of H2N-PEG2-CH2COOtBu is usually carried out by the following steps:
1. Firstly, ethylene glycol dimethyl ether and tributyl hexafluorophosphate are reacted to generate PEG group acryloyl chloride derivative;
2. Then the acryloyl chloride derivative is reacted with tert-butyl alcohol to generate tert-butyl ester PEG Group;
3. Finally, the tert-butylated PEG group is reacted with aminoethanol to generate the target compound H2N-PEG2-CH2COOtBu.
Safety Information:
No specific toxicity or danger has been reported H2N-PEG2-CH2COOtBu. However, when handling any organic compound, appropriate laboratory safety measures, such as wearing protective gloves and eye protection equipment, should be taken to ensure that the operation is carried out in a well-ventilated environment. Before use, it is recommended to refer to the relevant safety data and technical instructions to follow the correct operating procedures and waste disposal methods.
Last Update:2024-04-09 21:00:56